X-ray Imaging

Spectral Library of Nanoparticle Contrast Agents

A spectral library that is adaptable to different needs, such as passive vs. targeted delivery via control of the nanoparticle size and surface functionalization.

 

Company Name

University of Notre Dame

Reference Number 1248

Market Sectors:

Bio / Life Sciences, Chemicals, Engineering, Medical, Nanotechnology

Operational Areas

Patient Healthcare, Research
 

Commercial Solutions

Increase Efficiency
 
 

Description:

A library of nanoparticle X-ray contrast agents for spectral (colour) CT imaging. These optimized imaging agents capitalize on the spectral differences in physiological fluids and soft tissues previously unutilized by monochromatic X-ray imaging.

The library will include spectral imaging agents comprised of nanoparticles with an X-ray attenuating core of nominal composition. In each case, the core will be encapsulated in a shell of tailored thickness to modulate the overall nanoparticle size and to provide a common surface chemistry for molecular functionalization. 

Nanoparticles of each composition will also possess a common size and surface structure (shell) suitable for ready surface functionalization, colloidal stability, deliverability, and ultimately cytocompatibility. These criteria lead to a common, but widely applicable, spectral library that is adaptable to different needs, such as passive vs. targeted delivery via control of the nanoparticle size and surface functionalization.

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